Acute phase diffuse alveolar damage
Han and Fan..
- hospital admission
- 6 months later.
- 62% residual CT abnormalities at 6 months.
- 35% of the total cohort with ?fibrotic-like?
- parenchymal bands,
- irregular interfaces [bronchovascular, pleural, or mediastinal],
- traction bronchiectasis, and/or honeycombing).
- remaining participants
- ground-glass opacification and
- interstitial thickening;
- 35% of the total cohort with ?fibrotic-like?
- 26% of patients had reduced gas exchange physiology.
- 62% residual CT abnormalities at 6 months.
- Important was
- link between ARDS and fibrotic-like changes at 6 months
-
The corona virus at 1/100 the size of a human cell, threatens the people on the earth which is 8000 X 1,609,344,000,000 its size.
Ashley Davidoff TheCommonVein.netThe corona virus at 1/100 the size of a human cell, threatens the people on the earth which is 8000 X 1,609,344,000,000 its size.
Ashley Davidoff TheCommonVein.netINHALATION
The virus enters the lungs and travels to the smallest parts of the lungs, tiny lung sacs called the alveoli where oxygen exchange takes place
Ashley Davidoff TheCommonVein.netCELLULAR INVASION
Corona virus invades the cells of the alveoli by using its spike glycoproteins. These spike proteins attach to the cell membrane and the virus can then enter the cell.
Ashley Davidoff TheCommonVein.netCELLULAR INVASION
Corona virus invades the cells of the alveoli by using its spike glycoproteins. These spike proteins attach to the cell membrane and the virus can then enter the cell.
Ashley Davidoff TheCommonVein.netINFLAMMATION
The virus replicates and invades more cells of the alveoli
As COVID-19 causes inflammation of the the lungs, infected fluid fills the lungs thus disrupting gas exchange.
Ashley Davidoff TheCommonVein.netPROGRESSION AS THE DISEASE SPREADS IN THE LUNGS
The infection starts in small basal segments
INFLAMMATION
The virus replicates and invades more cells of the alveoli
As COVID-19 causes inflammation of the the lungs, infected fluid fills the lungs thus disrupting gas exchange.
Ashley Davidoff TheCommonVein.netPROGRESSION AS THE DISEASE SPREADS IN THE LUNGS
The infection starts in small basal segments
Ashley Davidoff TheCommonVein.netPROGRESSION
and progresses to involve more and more lung
Ashley DavidoffPROGRESSION
and progresses to involve more and more lungINITIAL PATCHY INVOLVEMENT
It spreads to both lungsMULTIFOCAL PNEUMONIA
Advancing infection involves more lung and prevents efficient and effective gas exchange (inhalation of oxygen and expiration of carbon dioxide). When this exchange is not possible, a ventilator is necessaryExtensive Disease With ARDS
39 COVID 004 current Organizing Pneumonia
COVID ILD 9 months post Acute Infection
- 6 months later.
Links and References
Wells et al editorial Radiology