- 40y.o. male recently diagnosed with atypical chronic myeloid leukemia (aCML) after presenting with fevers and malaise
- Associated findings
- Splenomegaly 15.5 cm
- transfusion-dependent macrocytic anemia and
- 10% circulating blasts with myeloid phenotype
- bone marrow biopsy
- suggested myeloproliferative disorder rather than AML,
- most consistent with CML,
- BCR/ABL1 FISH negative.
- Recommendation
- Stem cell Tx and
- Venetoclax
- Inqovi
- most consistent with CML,
- CXR 3 MONTHS AGO AT TIME OF PRESENTATION
-
40M atypical CML 01 CXR 3 months ago at time of diagnosis
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Ashley Davidoff MD40M-atypical-CML-02-CXR-3-months-ago-at-time-of-diagnosisb-e1658863188477.jpg
40M atypical CML 01 CXR 3 months ago at time of diagnosis
thecommonvein.net
Ashley Davidoff MD40M atypical CML 01 CXR 3 months ago at time of diagnosis
thecommonvein.net
Ashley Davidoff MD40M atypical CML 01 CXR 3 months ago at time of diagnosis
thecommonvein.net
Ashley Davidoff MD40M atypical CML 01 CXR 3 months ago at time of diagnosis
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Ashley Davidoff MD3 months later after starting chemotherapy
- complained of dyspnea
- CXR
- CXR post chemo shows left lower lobe subsegmental infiltrate and prominent interstitial changes at the bases
- CT scan
- subsegmental consolidative opacity in the left lower
lobe in a background of- diffuse bilateral segmental and subsegmental
airway disease - groundglass changes
- mosaic attenuations and
- some nodular
infiltrates.
- diffuse bilateral segmental and subsegmental
- Infectious, inflammatory immunologic (lung toxicity ) etiologies are considered
- suggested myeloproliferative disorder rather than AML,

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Ashley Davidoff MD
40M-atypical-CML-08-CXR-current-post-chemo-lung-bases.jpg
40M atypical CML 07 CXR current post chemo shows left lower lobe subsegmental infiltrate and prominent interstitial changes at the bases as wellthecommonvein.net
Ashley Davidoff MD
CT Scan

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Ashley Davidoff MD

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Ashley Davidoff MD

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Ashley Davidoff MD

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Ashley Davidoff MD

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Ashley Davidoff MD

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Ashley Davidoff MD

thecommonvein.net
Ashley Davidoff MD