Location 3

The Virus

The shape of the corona virus causing COVID-19 bears similarity with the flower of the Buttonbush pictured above

The Bat ? A Common Carrier

ONE OF THE SOURCES Infected bat
Image of the bat ? courtesy Oren Peles

Wet Market ? Source of Infected Animals

Wet market selling live and dead bats, fish, badgers, turtles, anteaters?

Contact and Contamination

Inhalation

Inhalation and Travel through the Airways

INHALATION
The virus enters the lungs and travels to the smallest parts of the lungs, tiny lung sacs called the alveoli where oxygen exchange takes place

Destination is the Alveolus and Alveoli

008a.jpg

CELLULAR INVASION
Corona virus invades the cells of the alveoli by using its spike glycoproteins. These spike proteins attach to the cell membrane and the virus can then enter the cell.

Invasion, Replication, and the Inflammatory Response

INFLAMMATION
The virus replicates and invades more cells of the alveoli
As COVID-19 causes inflammation of the the lungs, infected fluid fills the lungs thus disrupting gas exchange.

Early Changes in the Small Segments of the Lung

PROGRESSION AS THE DISEASE SPREADS IN THE LUNGS
The infection starts in small basal segments

INITIAL PATCHY INVOLVEMENT
It spreads to both lungs

Progressive Disease Involving Larger Segments

PROGRESSION
and progresses to involve more and more lung

MULTIFOCAL PNEUMONIA
Advancing infection involves more lung and prevents efficient and effective gas exchange (inhalation of oxygen and expiration of carbon dioxide). When this exchange is not possible, a ventilator is necessary

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The Common Vein

Location 3

The Virus

The Bat ? A Common Carrier

Wet Market ? Source of Infected Animals

Contact and Contamination

Inhalation

Inhalation and Travel through the Airways

Destination is the Alveolus and Alveoli

Invasion, Replication, and the Inflammatory Response

Early Changes in the Small Segments of the Lung

Progressive Disease Involving Larger Segments

TCV

The Bat ? A Common Carrier

Wet Market ? Source of Infected Animals

Contact and Contamination

Inhalation

Inhalation and Travel through the Airways

Destination is the Alveolus and Alveoli

Invasion, Replication, and the Inflammatory Response

Early Changes in the Small Segments of the Lung

Progressive Disease Involving Larger Segments

Related Links

TCV